Equine Multinodular Pulmonary Fibrosis Associated with Equine Herpesvirus 5 in a Horse in Brazil

Authors

  • Welden Panziera Programa de Pós-Graduação em Medicina Veterinária, área de concentração em Patologia e Patologia Clínica, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), Bairro Camobi, Santa Maria, RS 97105-900, Brazil. Author
  • Paula R. Giaretta Programa de Pós-Graduação em Medicina Veterinária, área de concentração em Patologia e Patologia Clínica, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), Bairro Camobi, Santa Maria, RS 97105-900, Brazil. Author
  • Glauco J. N. Galiza Programa de Pós-Graduação em Medicina Veterinária, área de concentração em Patologia e Patologia Clínica, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), Bairro Camobi, Santa Maria, RS 97105-900, Brazil. Author
  • Ailam Lim Diagnostic Center for Population and Animal Health, Michigan State University, 4125 Beaumont Road, Lansing, MI 48910-8104, USA. Author
  • Steven R. Bolin Diagnostic Center for Population and Animal Health, Michigan State University, 4125 Beaumont Road, Lansing, MI 48910-8104, USA. Author
  • Carlos H. Borges Veterinary Surgeon, Equine Practicioner, Bagé, Rio Grande do Sul, Brazil. Author
  • Rafael A. Fighera Departamento de Patologia, Centro de Ciências da Saúde, UFSM, Av. Roraima 1000, Santa Maria, RS, Brazil, 97105-900 Author
  • Claudio S. L. Barros Departamento de Patologia, Centro de Ciências da Saúde, UFSM, Av. Roraima 1000, Santa Maria, RS, Brazil, 97105-900 Author

Keywords:

EHV-5, equine multinodular pulmonary fibrosis, herpesviruses, horse, pneumonia, respiratory

Abstract

This report describes the first diagnosed case of equine multinodular pulmonary fibrosis associated with equine herpesvirus 5 (EHV-5) in a horse in Brazil. A 7-year-old Thoroughbred mare from a stud farm in southern Brazil died after a chronic respiratory disease characterized by tachypnea, respiratory distress, and cough accompanied by weight loss, anorexia, and intermittent fever. Hematological findings included mild neutrophilia, lymphopenia, and hyperfibrinogenemia. At necropsy the cadaver was extremely emaciated and the lungs did not collapse when the rib cage was removed. Significant gross lesions were restricted to the lungs and consisted of numerous, firm, coalescing nodules widely distributed throughout the organ. The nodules were 1-5 cm in diameter, pale tan-white, and sharply demarcated from the scant normal lung parenchyma. Microscopically, the nodules consisted of marked expansion of the interstitium by wellorganized, mature collagen and infiltration by lymphocytes, macrophages, neutrophils and occasional eosinophils. Cuboidal epithelial cells lined the alveoli in affected areas and their lumina were filled with a moderate to high number of neutrophils and foamy macrophages, which occasionally displayed oval amphophilic intranuclear inclusion bodies. Nucleic acid sequence analyses of amplicons from polymerase chain reaction assays targeting the viral gBand gHgenes showed closest homology with multiple corresponding sequences of the gB and gH genes of EHV 5 available in GenBank.

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Published

2014-03-30

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Artigos

How to Cite

Panziera, W., Giaretta, P. R., Galiza, G. J. N., Lim, A., Bolin, S. R., Borges, C. H., Fighera, R. A., & Barros, C. S. L. (2014). Equine Multinodular Pulmonary Fibrosis Associated with Equine Herpesvirus 5 in a Horse in Brazil. Brazilian Journal of Veterinary Pathology, 7(1), 17-20. https://bjvp.org.br/bjvp/article/view/167