Multidrug therapy for muscular dystrophy in a GRMD (Golden Retriever muscular dystrophy) model

Authors

  • Renata A. Fernandes Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil Author
  • Paula Fratini Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil Author
  • José L. Nogueira Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil Author
  • Dilayla K. Abreu Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil Author
  • David Feder School of Medicine ABC, Santo Andre, SP, Brazil. Author
  • Ana Claudia O. Carreira Internal Medicine Department, School of Medicine and Institute of Chemistry, Universidade de São Paulo, São Paulo, SP, Brazil. Author
  • Maria A. Miglino Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil Author

Keywords:

treatment, disease of dogs, muscle diseases, canine dystrophy

Abstract

Golden Retriever muscular dystrophy (GRMD) is a degenerative, progressive and lethal genetic disease, homologous to human Duchenne muscular dystrophy (DMD). For both there is no cure and clinical interventions are limited to treating clinical signs. As potential treatment, we did a pilot study in GRMD and administered a cocktail of frequently used drugs that might work synergistically. Biochemical blood values were investigated and histology and real-time PCR of muscle biopsies were performed. Significant improvements occurred in experimental Golden Retrievers dogs in regard to the levels of alanine aminotransferase, neutrophils, lymphocytes and CK, which began to show values closer to normal ones when compared to control animals, as well as moderate inflammatory infiltrates in the musculature, according to histology. The drug cocktail seemed to work systemically, but did not interfere with the gene defect, thus having potential value for maintaining the health status and preventing the progression of muscular dystrophy in GRMD model.

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Published

2016-11-30

Issue

Section

Artigos

How to Cite

Fernandes, R. A., Fratini, P., Nogueira, J. L., Abreu, D. K., Feder, D., Carreira, A. C. O., & Miglino, M. A. (2016). Multidrug therapy for muscular dystrophy in a GRMD (Golden Retriever muscular dystrophy) model. Brazilian Journal of Veterinary Pathology, 9(3), 88-92. https://bjvp.org.br/bjvp/article/view/220