Pathology of natural cases of ovine pulmonary adenocarcinoma (Jaagsiekte) in goats

Authors

  • V. Rama Devi Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • B.B. Manasa Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • V. Samatha Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • M. Mahesh Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • K.V. Srikanth Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • T. Yathiraja Rao Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • K. Satheesh Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author
  • K.V.S. Nanda Kishore Department of Veterinary Pathology, NTR College of Veterinary Science. Gannavaram, A.P, India Author

Keywords:

goat, JSRV, lung, OPA, pathology

Abstract

The pathological findings and the immunohistochemical and molecular diagnosis of two natural cases of pulmonary adenocarcinoma in goats are described. Ovine pulmonary adenocarcinoma (OPA), a contagious lung tumor, caused by an exogenous Jaagsiekte Sheep Retrovirus (JSRV), is reported commonly in sheep and rarely in goats. The affected lungs had a focally extensive and firm nodule or multiple nodules on the cranioventral region. On the cut surface, the nodules were greyish, granular and moist, resembling classical form of OPA. Microscopically, the lung sections showed unencapsulated nodules of neoplastic epithelial cells, from alveoli and bronchioles, forming papillary projections or acini. On the immunohistochemical analysis, JSRV capsid protein was demonstrated in the neoplastic epithelial cells. Genomic DNA was extracted from the lung tumor tissues and was subjected to U3-hn-PCR that further confirmed the presence of JSRV. The pathological findings in goats were similar to that of OPA affecting lungs of sheep and, to the author’s knowledge, this is the first report of the disease in goats with immunohistochemical and PCR confirmation of JSRV.

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Published

2016-11-30

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Section

Artigos

How to Cite

Devi, V. R., Manasa, B., Samatha, V., Mahesh, M., Srikanth, K., Yathiraja Rao, T., Satheesh, K., & Nanda Kishore, K. (2016). Pathology of natural cases of ovine pulmonary adenocarcinoma (Jaagsiekte) in goats. Brazilian Journal of Veterinary Pathology, 9(3), 108-112. https://bjvp.org.br/bjvp/article/view/224