Cholangiocarcinoma with splenic metastasis in a red-tailed amazon (Amazona brasiliensis)

Isabela Coelho Zanoti; Bruno Simões Sérgio Petri; Haroldo Ryoiti Furuya; Luciana Greyce do Nascimento Souza; Valéria da Silva Pedro; Beatriz Azevedo Cezila; Liliane Milanelo; Lilian Sayuri Fitorra

doi:10.24070/bjvp.1983-0246.018017

Authors

Isabela Coelho Zanoti Magnani & Paschoal Assessoria Ambiental Ltda, São Carlos, SP, Brazil Author https://orcid.org/0009-0008-6547-9434
Bruno Simões Sérgio Petri Magnani & Paschoal Assessoria Ambiental Ltda, São Carlos, SP, Brazil Author https://orcid.org/0000-0002-9662-9289
Haroldo Ryoiti Furuya Magnani & Paschoal Assessoria Ambiental Ltda, São Carlos, SP, Brazil Author https://orcid.org/0000-0002-0494-3888
Luciana Greyce do Nascimento Souza Magnani & Paschoal Assessoria Ambiental Ltda, São Carlos, SP, Brazil Author https://orcid.org/0009-0003-9756-6077
Valéria da Silva Pedro Centro de Triagem e Reabilitação de Animais Silvestres (CETRAS São Paulo), Diretoria de Biodiversidade e Biotecnologia, Secretaria de Meio Ambiente, Infraestrutura e Logística, São Paulo, SP, Brazil Author https://orcid.org/0000-0001-7279-6229
Beatriz Azevedo Cezila Magnani & Paschoal Assessoria Ambiental Ltda, São Carlos, SP, Brazil Author https://orcid.org/0000-0002-4943-207X
Liliane Milanelo Centro de Triagem e Reabilitação de Animais Silvestres (CETRAS São Paulo), Diretoria de Biodiversidade e Biotecnologia, Secretaria de Meio Ambiente, Infraestrutura e Logística, São Paulo, SP, Brazil Author https://orcid.org/0000-0001-9966-4410
Lilian Sayuri Fitorra Centro de Triagem e Reabilitação de Animais Silvestres (CETRAS São Paulo), Diretoria de Biodiversidade e Biotecnologia, Secretaria de Meio Ambiente, Infraestrutura e Logística, São Paulo, SP, Brazil Author https://orcid.org/0000-0001-6990-1120

DOI:

https://doi.org/10.24070/bjvp.1983-0246.018017

Keywords:

avian pathology, neoplasm, immunohistochemistry

Abstract

Cholangiocarcinoma is a tumor originating from the epithelium of the biliary ducts that has been frequently reported in birds, particularly within the order Psittaciformes. A red-tailed amazon (Amazona brasiliensis) was voluntarily delivered to the Centro de Triagem e Recuperação de Animais Silvestres (CETRAS), in the Parque Ecológico do Tietê (São Paulo municipality, São Paulo state, Brazil), showing signs of prostration and respiratory distress. Despite supportive care, the bird died seven days after admission. Necropsy revealed cachexia and multiple small yellowish nodules scattered across the hepatic surface and extending into the parenchyma. Histopathological examination of the liver showed epithelial cell proliferation forming tubular structures within a moderately collagenous stroma, suggestive of cholangiocarcinoma. Immunohistochemical analysis of hepatic tissue was performed using a diagnostic panel including AE1/AE3, CK7, and HepPar-1. Only AE1/AE3 yielded a positive result, confirming the diagnosis of cholangiocarcinoma. This is the first report of cholangiocarcinoma in a red-tailed amazon. We highlight the importance of proper nutritional management to reduce the likelihood of neoplastic disease development, thus improving quality of life and increasing life expectancy in captive birds.

References

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Cholangiocarcinoma with splenic metastasis in a red-tailed amazon (Amazona brasiliensis)

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