Brazilian Journal of Veterinary Pathology
The purpose of the Brazilian Journal of Veterinary Pathology (BJVP), a peer-reviewed journal, is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.
Toxic gastritis in a llama (Lama glama) caused by spontaneous Baccharis coridifolia DC. ("mio-mio") poisoning in the Santa Catarina Plateau, Brazil
This report describes the first known spontaneous case of B. coridifolia poisoning in a domesticated llama. In August 2023, the death of a 10-month-old female llama was reported on a farm in the Santa Catarina Plateau, Brazil. The affected llama had been acquired 2 months earlier from Paraná and initially kept with sheep on ryegrass pasture. One day before death, it was moved to a native field heavily invaded with B. coridifolia. Clinical signs included polydipsia and muscle tremors, progressing rapidly to death approximately 14 h after the onset of clinical signs. At necropsy, the 1st and 2nd gastric compartments (C1 and C2) contained abundant fibrous ingesta and exhibited mild mucosal congestion. In the 3rd gastric compartment (C3), mild to moderate congestion, predominantly affecting the caudal region, was observed. Histopathology revealed marked diffuse mucosal necrosis with inflammatory infiltrates predominantly composed of neutrophils and macrophages, and mild edema in the aglandular portions of C1 and C2. In C3, mild to moderate congestion was observed. Additional findings included pulmonary congestion and edema, renal congestion, and centrilobular hepatocellular degeneration. Specimens of B. coridifolia collected from the property were submitted to the Herbarium Lages of the State University of Santa Catarina (LUSC) for botanical confirmation. The epidemiological, clinical, and pathological findings supported the diagnosis of B. coridifolia (mio-mio) toxicosis.This case underscores the importance of proper pasture management and careful monitoring when relocating animals to areas containing known toxic plants.
Copyright (c) 2026 Brazilian Journal of Veterinary Pathology https://creativecommons.org/licenses/by/4.0
Assessment of pulmonary lesions associated with Porcine Respiratory Disease Complex in Colombian swine herds using slaughterhouse lung scoring systems
Porcine Respiratory Disease Complex (PRDC) causes substantial economic losses in swine production due to decreased efficiency and increased reliance on pharmaceuticals for disease control. Diagnosis of PRDC can be achieved by evaluating lung lesions at slaughterhouses, which enables assessment of herd health status and the formulation of targeted control strategies. In this study, the MADEC and SPES scoring systems were employed to characterize lung lesions associated with PRDC in pigs slaughtered in Colombia. A total of 16,223 red viscera (lungs, heart, and liver) from 15 commercially advanced farms were examined, utilizing the MADEC system for cranioventral consolidations and the SPES system for dorsocaudal pleuritis. Additionally, histopathological analyses and multiplex PCR tests were performed on randomly selected samples to identify microscopic lesions and respiratory pathogens. Approximately 70% of diaphragmatic lobes on both sides exhibited mild lesions (MADEC1), while severe lesions (MADEC3–4) were predominantly observed in the cardiac and accessory lobes. The prevalence of pleuritis was 17.7%, with SPES types 1 and 2 being most common. Glaserella parasuis was the only pathogen detected in the analyzed samples. Furthermore, concurrent use of up to five antimicrobial groups was documented across the farms. In conclusion, the observed respiratory lesions likely reflect the widespread circulation of PRDC agents, underscoring the need to enhance biosecurity, vaccination programs, and epidemiological surveillance in Colombian swine production. The adoption of standardized systems, such as MADEC and SPES, facilitates effective monitoring and control of respiratory diseases throughout the production chain.
Cervical stenotic myelopathy in a Brazilian Sport Horse foal
Cervical stenotic myelopathy (CSM) is a neurological disorder characterized by spinal cord compression in the cervical region, frequently associated with ataxia in horses. The objective of this study was to report a case of cervical stenotic myelopathy in a Brazilian Sport Horse filly evaluated at the Veterinary Hospital of the Federal University of Mato Grosso, Cuiabá campus, describing the clinical history, epidemiological factors, radiographic and tomographic findings of the cervical region, and post mortem findings. The animal presented with a history of frequent falls, incoordination and Increased volume in the femoral region of the right pelvic limb.. Laboratory tests showed no significant abnormalities, and swelling in the pelvic limb was compatible with a hematoma. Cervical radiographs revealed spinal canal stenosis between C3 and C4. After death, computed tomography associated with myelography demonstrated greater compression at this level during cervical flexion, with sagittal ratio values consistent with stenosis. Morphological evaluation of the cervical vertebrae indicated articular incongruence suggestive of cervical instability, and histopathology of the spinal cord revealed degenerative changes consistent with cervical stenotic myelopathy. These results highlight the importance of combining clinical evaluation, imaging studies, and anatomopathological analysis for definitive diagnosis and emphasize the diagnostic complexity of this condition, especially in young animals with nonspecific neurological signs.
Histological heart lesions resembling myocardial dysplasia in a Guiana Dolphin (Sotalia guianensis) necropsied on the coast of Ceará, Brazil
Myocardial dysplasia, also known as arrhythmogenic right ventricular cardiomyopathy (ARVC), is a degenerative condition characterized by the progressive replacement of the myocardium by fibroadipose tissue, impairing cardiac electrical conduction and predisposing to arrhythmias and sudden death. Although well described in humans and in certain canine breeds, such as Boxers, it is rarely reported in veterinary medicine, especially in marine mammals. This study describes a case in a Guiana dolphin (Sotalia guianensis), stranded on the coast of Ceará, Brazil, which underwent necropsy and histopathological analysis, revealing replacement of myocardial tissue by adipose and fibroadipose tissue in the free wall of the right ventricle, with extension to the subendocardial region, without signs of myocarditis. Despite sampling limitations, the observed lesion pattern is consistent with ARVC-like changes and should be interpreted with caution in light of the possible occurrence of physiological lipomatosis in cetaceans, which has not yet been described in this species. These findings suggest that patterns similar to those observed in other species may occur in cetaceans, contributing to the understanding of cardiac diseases in this group and reinforcing the importance of detailed histopathological evaluation in stranded marine animals. Furthermore, the need for additional studies is highlighted, especially in regions under significant anthropogenic influence.
Extragonadal mature teratoma in a 6-months-old kitten
Germ cell tumors can be classified as teratoma, embryonal carcinoma, yolk sac carcinoma, dysgerminomas and seminomas. Teratomas are composed by well-differentiated cells from at least two of the three embryonic layers, and are more commonly in ovaries or testicles, but can occur extragonadal. This case describes a subcutaneous mature teratoma in a 6-month-old kitten. Macroscopically, the tumor was multilobulated and firm, measuring 11 x 6,5 x 5cm; on cut surface, multiple cystic cavities, solid white areas and hard portions. Histologically, cells derived from the three layers were present – hair follicles and glands, nervous tissue, odontogenic epithelium, respiratory epithelium, and different mesenchymal cells (bone, adipocytes, muscle fibers and fibrous tissue). Immunolabeling for pancytokeratin, vimentin, GFAP and p40 were strong in the different types of cells, and no immature tissue was seen. So, the tumor was classified as a mature extragonadal teratoma. The mass was completely excised and no recurrence was seen.
PRAME immunoexpression in canine melanocytic tumors: a case series study
Diffuse immunoexpression of Preferentially Expressed Antigen in Melanoma (PRAME) is an ancillary diagnostic tool for distinguishing human melanoma from melanocytic nevi. Canine melanocytic neoplasms are common in veterinary diagnostic practice; however, no established immunohistochemical biomarkers of malignancy are currently available. This case series study aimed to investigate the immunoexpression of the anti-PRAME (EPR20330) antibody in canine melanocytic tumors. Two cutaneous melanocytomas and six melanomas from distinct anatomical sites (haired skin, oral cavity and feet) were submitted to immunohistochemistry protocol with anti-PRAME antibody (clone EPR20330, dilution 1:100, Abcam) overnight at 4°C. Nuclear immunolabeling was scored on a 5-point scale based on the percentage of positive tumor cells (0: none; 1: 1–25%; 2: 26–50%; 3: 51–75%; 4/diffuse: ≥76%). The two evaluated melanocytomas were PRAME-negative. All melanomas were PRAME-positive and diffuse nuclear immunolabeling was observed in 4/6 cases. To the best of our knowledge, this is the first study to demonstrate the immunohistochemical expression of the anti-PRAME antibody (clone EPR20330) in canine melanomas. Our preliminary findings, based on a limited sample size, suggest that PRAME may represent a promising ancillary diagnostic marker for these tumors, similar to its use in human samples. However, further studies with larger cohorts are needed to better characterize its labeling patterns in canine melanocytic neoplasms and to confirm its diagnostic value in veterinary pathology.
Chronic exfoliative dermatitis in a German Shorthaired Pointer dog
History: A 5-year-old, spayed female, German Shorthaired Pointer dog presented to a veterinary clinic for a second opinion following a history of chronic dermatitis and suspected allergies. Clinical signs improved with prednisone, but there was no appreciable response with antibiotics or oclacitinib (Apoquel). Lesions initially developed on the chest and occasionally involved paw pads and lips.
Granulomatous hepatitis associated with plant material in a cat
History: A three-year-old, female, mixed-breed, FeLV-positive cat, with a history of suture dehiscence and evisceration following a previous ovariohysterectomy at an unspecified time, was presented with dyspnea, prostration, decreased level of consciousness, and abdominal distension, in addition to pleural and pericardial effusion. Cytological evaluation of the pleural fluid revealed high cellularity composed of neoplastic lymphoid cells. Thoracic radiographs demonstrated increased volume and opacity of the mediastinum, associated with dorsal tracheal displacement. Due to the presumptive diagnosis of lymphoma, the severity of the clinical signs, and the lack of response to supportive treatment, euthanasia was elected.
Malignant melanoma in a lamb: clinical and pathological findings
Melanoma is a rare neoplasm in small ruminants, particularly in sheep, and is uncommon in young animals. This study describes the clinical, cytological, histopathological, and immunohistochemical findings of a melanoma in a lamb. A three-month-old female sheep presented with a progressively growing mass in the left periauricular region, first observed at 45 days of age. Cytological evaluation revealed atypical cellular proliferation with marked pleomorphism and mitotic figures, suggesting a malignant neoplastic process. Imaging examinations demonstrated increased soft-tissue volume without evidence of bone involvement. Surgical excision was performed for both diagnostic and therapeutic purposes. Histopathological examination revealed a non-encapsulated, densely cellular, infiltrative neoplasm predominantly composed of epithelioid cells, with marked anisocytosis and anisokaryosis, a high mitotic index, intracytoplasmic melanin pigment, and areas of necrosis. Immunohistochemical analysis showed positive immunostaining for S100 and Melan-A, confirming the melanocytic origin of the neoplasm. Despite surgical removal, rapid local recurrence and clinical deterioration were observed, culminating in death within 30 days, indicating aggressive biological behavior and possible metastatic dissemination. This report demonstrates that, although rare in sheep, melanoma can occur in young animals and may progress rapidly, with a poor prognosis, highlighting the importance of an integrated diagnostic approach and its inclusion in the differential diagnosis of cutaneous masses in lambs.
Intramedullary dermoid cyst associated with Wallerian degeneration in a dog
Dermoid cysts are benign congenital lesions of ectodermal origin lined by stratified squamous epithelium and containing cutaneous adnexal structures, keratin debris, and sebaceous material. These lesions are commonly identified in the skin of dogs and cats, particularly along embryonic fusion lines. Occurrence within the central nervous system is uncommon and intramedullary localization is exceptionally rare. This report describes an intramedullary dermoid cyst associated with Wallerian degeneration in an eight-month-old female Boxer dog presenting with a one-month history of paraplegia, self-mutilation of the right pelvic limb paw, and loss of deep pain perception. Due to severe neurological dysfunction, euthanasia was performed and the animal was submitted for pathological examination. Gross examination revealed a 2 cm thin-walled, pearly white cystic lesion located within the L4–S3 spinal cord segments, containing friable brownish material with keratin filaments. Histopathological examination demonstrated a cyst lined by well-differentiated stratified squamous keratinizing epithelium with a prominent stratum granulosum and abundant orthokeratotic laminated keratin within the lumen. Cutaneous adnexal structures, including sebaceous and apocrine glands, were observed within the cyst wall. Adjacent spinal cord tissue exhibited severe compression, focal malacia, and Wallerian degeneration characterized by digestion chambers and gitter cells. Immunohistochemically, the epithelial lining showed strong cytokeratin immunostaining and absence of vimentin expression, whereas stromal and adnexal components were vimentin-positive. The morphological diagnosis was an intramedullary dermoid cyst associated with Wallerian degeneration. This report highlights the rare intramedullary presentation of dermoid cysts in dogs and reinforces the importance of histopathological and immunohistochemical evaluation for definitive diagnosis.
Follicular thyroid carcinoma in a domestic pigeon (Columba livia)
A 10-year-old female domestic pigeon (Columba livia), presented with marked depression, hyporexia, and scant green droppings for approximately two weeks, according to the owners. On general physical examination, a nodule was detected in the subcutaneous tissue at the level of the crop. Due to the bird´s poor prognosis, euthanasia was performed. At necropsy, an oval mass was found in the subcutaneous tissue of the ventral region of the distal third of the neck, located above the crop and adjacent to the trachea. The mass measured 3.5 x 2.2 x 1.5 cm, was light brown, had a slightly irregular and firm consistency, and on cut section showed small cavitations. The tissue was submitted to Departamento de Patología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, for histological evaluation, where it was diagnosed as follicular thyroid carcinoma. In birds, thyroid neoplasms have been reported as incidental findings and their prognosis is usually poor. Antemortem diagnosis is difficult because birds tend to show nonspecific clinical signs; therefore, in most cases, the definitive diagnosis is made postmortem. Although papillary thyroid adenomas have previously been reported in pigeons, the aim of the present study is to report the first case of follicular thyroid carcinoma in a domestic pigeon.
Mycoplasmosis infection with secondary heterophilic andnecrotizing blepharoconjunctivitis and sinusitis in a chicken
History: A 3-months-old male Belgian Bearded d’Uccle chicken was presented together with two other juvenile chickens for progressive ocular and respiratory disease. The birds had been previously treated with oxytetracycline and topical ophthalmic antibiotics, including Tricin® ointment and chloramphenicol eye drops, without clinical improvement. Clinical signs progressively worsened. At presentation, all birds exhibited ocular lesions. The Belgian d’Uccle chick showed bilateral periocular distension and deformation, with complete obscuration of the left eye. Respiratory effort was increased, with audible crackles consistent with air sac involvement. The oral cavity was malodorous. Feces were light brown and loose, and the bird was markedly emaciated. Two of the affected chickens, including the Belgian d’Uccle chick, were bred on the owner’s property from a newly introduced rooster. The third bird was an unrelated Showgirl cockerel purchased as a day-old chick that subsequently developed similar clinical signs.
History: 6-year-old, neutered male, goat was submitted for necropsy. Clinical history included 3 weeks of lameness following possible trauma which was gradually improving. The day prior to euthanasia this goat was acutely lethargic and anorexic. On physical exam, the goat was thin and weak. The animal was euthanized due to quality-of-life concerns.
Fibrous osseous dystrophy and early-onsetchronic kidney disease from renal dysplasia in a juvenile dog
History: A postmortem examination was performed on an 8-month-old, intact female crossbred dog that was humanely euthanized following an acute onset of vomiting, diarrhea, and lethargy. The animal had renal azotemia, chronic kidney disease and small stature.
History: A 5-year-old female spayed domestic shorthair initially presented to oncology services for a 4-month history of a subcutaneous mass on the right side of the mandible that extended into the mouth. The right eyeball had been previously enucleated one year prior due to an undisclosed reason. At presentation, the animal was having difficulty eating and breathing. Due to concerns for quality of life, humane euthanasia was elected.
Malignant catarrhal fever and Clostridium perfringens co-infection in White-Spotted Deer: a fatal encounter
Malignant Catarrhal Fever (MCF) is one of the diseases reported as a transboundary disease, which is commonly caused by Alcelaphine herpesvirus 1 (AlHV-1) and Ovine herpesvirus 2 (OvHV-2). Cervidae (Deer) are susceptible to this virus infection, with the outbreak occurring sporadically. A total of 5 out of 42 deer were presented with sudden death and weakness, with bloody diarrhea ranging from a few days to 24 hours before death. Gross and histopathological evaluations revealed severe haemorrhagic enteritis, pulmonary edema, and widespread necrotizing vasculitis observed in the lung, liver, and kidney. Diagnostic laboratory testing revealed a positive result of MCF (OvHV-2) virus from the lung samples through Polymerase chain reaction (PCR). Anaerobic culture, PCR and sequencing of the intestinal sample were positive for C. perfringens. Following the deaths of 2 deer, examination of the feed revealed an unplanned dietary transition from deer pellet to goat pellet with the differences in the protein content (min 14%) with mostly grains and higher moisture content (max 13%) in the goat pellet, leading to possible changes in the gastrointestinal flora of the deer gut which causes proliferation of C. perfringens. Presence of OvHV-2 targets the CD8+ lymphocytes that induce systemic inflammation, causing widespread vascular injury, which further promotes proliferation of C. perfringens that contributes to the severity of the enteritis observed. The resulting necrohaemorrhagic enteritis leads to hypovolemic shock, ultimately death due to circulatory failure. This report highlights the review, presents findings, transmission and pathology of Malignant Catarrhal Fever and C. perfringens in white spotted deer.
Carcinoma with medullary signs in mammary glands in cats: morphohistological study and immunohistochemical analysis
Breast carcinoma in cats is a serious oncological problem, especially considering that such tumors can cause metastasis to the lymph nodes and other organs. This article considers five cases of carcinoma with medullary signs in cats, of which two have metastases in regional lymph nodes. The morphohistological characteristics of tumors and the results of an immunohistochemical study using NCL and NPM1 markers are analyzed in detail.
Wildfire-related lesions in a free-ranging Paraguayan Hairy Dwarf Porcupine (Coendou spinosus) in Brazil
The impacts of wildfire smoke on the health and behavior of wildlife are largely unknown and a few studies have explicitly considered the impact of wildfire smoke inhalation on the health of wildlife. Veterinarians should be aware of how animals behave during forest fires and the lesions are most common in different groups of animals. We describe here the injuries found in a porcupine that was a victim of wildfire, in a State Park, after a balloon crash. Despite the care provided, the animal died. At necropsy, it showed singed fur, erythema on the skin, swollen lungs, and congestion in the kidney. Microscopic examination revealed pulmonary edema, carbon pigmentation in the alveoli, liver degeneration, acute tubular injury in the kidney, and cardiac hemorrhage. The cardiorespiratory lesions were the most significant finding and were associated with the cause of death. These findings are a warning sign, since rescue veterinarians are often concerned primarily with providing support for burns visible on physical examination, neglecting cardiorespiratory function and metabolic changes that may be present. Necropsy of an animal killed by a forest fire should always be encouraged, as it can help clarify the events that occurred, allows comparative pathology and develop intensive care protocols, reducing the loss of life.
Unilateral segmental aplasia of the epididymis and ductus deferens in a mixed-breed dog
A 9-month-old male mixed-breed dog was presented for elective bilateral orchiectomy. During the procedure, segmental aplasia of the tail of the right epididymis and absence of the corresponding ductus deferens were observed. Additionally, the head of the epididymis on the affected side appeared enlarged. Histopathological examination revealed multiple sperm granulomas with inflammatory infiltrate composed of macrophages, multinucleated giant cells, neutrophils, lymphocytes, and plasma cells, as well as fibrosis. The epididymal tail and ductus deferens were absent. These gross and microscopic findings supported a diagnosis of segmental aplasia of the epididymis and ductus deferens.
Neoplasia of glandular and blood vessel origin in Canis familiaris: diagnostic and therapeutic approach
Cutaneous neoplasms in dogs are common findings in routine veterinary practice, especially in older animals. Among these, adenoma and hemangioma stand out, both of benign nature but capable of causing discomfort and the risk of secondary complications. This paper reports the case of a 7-year-old mixed-breed male dog weighing 5 kg, which presented two distinct nodular formations: a subcutaneous lesion on the right dorsal region and another at the base of the tail. The first was identified as a hepatoid cell adenoma, and the second as a hemangioma, both confirmed by histopathological examination after surgical excision. The clinical case highlights the importance of early evaluation of skin masses, precise surgical management, and diagnostic differentiation between tumor types, in accordance with current veterinary oncology guidelines.
Fatal canine metaldehyde poisoning in Southern Brazil
Metaldehyde is commonly used as a molluscicide, and accidental ingestion in dogs is a recognized toxicologic emergency with potentially fatal outcomes. A 4-month-old female Pit Bull was presented to a veterinary emergency after ingesting an unknown amount of a 5% metaldehyde-based slug bait (Metarex®). Clinical signs began within minutes and included stupor, hypersalivation, and generalized tonic-clonic seizures. Supportive care was provided, including anesthetic coma with propofol and isoflurane, gastric lavage, diazepam, N-acetylcysteine, and oxygen therapy; however, the animal died in eight hours. At necropsy, the stomach and intestines contained abundant blue-to-green amorphous and finely granular material, as well as plastic fragments consistent with Metarex® packaging. No significant microscopic alterations were observed in internal organs. The diagnosis was based on the clinical course, history of exposure, and characteristic gastrointestinal contents. In suspected cases, identification of metaldehyde in the gastrointestinal tract can aid diagnosis when toxicologic confirmation is unavailable.
Granulomatous posthitis caused by Halicephalobus gingivalis in association with penile squamous cell carcinoma in an equine: clinical and anatomopathological aspects
Penile and preputial squamous cell carcinomas are among the most common tumors in horses, and inflammation of the external genitalia caused by Halicephalobus gingivalis is an important differential diagnosis. H. gingivalis is a free-living nematode that causes fatal parasitic encephalitis in horses and humans and can eventually be diagnosed in the kidneys, lymph nodes, lungs, genital and ocular mucosa. The objective was to characterize clinical and pathological lesions caused by H. gingivalis infection in the prepuce with concomitant involvement of penile squamous cell carcinoma in an equine. A 15-year-old male Pampa horse with prepuce and penis ulcerated lesions had these surgically excised. Histopathological analysis revealed granulomatous posthitis with H. gingivalis intralesional and ulcerated penile squamous cell carcinoma. The animal had a satisfactory clinical and surgical evolution, and there was no recurrence of the lesions after a six-month follow-up period. Considerations regarding the route of infection, treatment, and zoonotic potential were highlighted, showing the importance of including this pathogen in the differential diagnosis of nodular lesions affecting the preputial and penile areas in horses.
Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e XII Simpósio Brasileiro da Davis-Thompson Foundation
É com grande satisfação que apresentamos os Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), realizado conjuntamente com o XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e o XII Simpósio Brasileiro da Davis-Thompson Foundation. Este importante evento científico ocorreu de forma totalmente remota, entre os dias 26 e 30 de julho de 2021, em um dos períodos mais desafiadores da história recente da humanidade, marcado pela pandemia da COVID-19. Mesmo diante das limitações impostas pelo distanciamento social e pelas incertezas daquele momento, o congresso demonstrou a força, a resiliência e o compromisso da comunidade científica da Patologia Veterinária com a produção e a disseminação do conhecimento. A realização do evento em formato virtual possibilitou ampla participação nacional e internacional, consolidando-se como um espaço plural de troca científica, atualização profissional e fortalecimento institucional da área. Esta edição do congresso contou com o maior número de palestrantes já registrado na história do CBPV, reunindo 67 especialistas provenientes de diferentes regiões do Brasil e de diversos países. Esses profissionais, mesmo vivenciando contextos locais igualmente desafiadores, aceitaram generosamente contribuir com o evento, compartilhando experiências, avanços científicos, abordagens diagnósticas e perspectivas futuras da Patologia Veterinária. Além das palestras, o evento recebeu um expressivo número de contribuições científicas, totalizando 301 resumos, apresentados na forma de pôsteres digitais, os quais estão reunidos nestes Anais. Os trabalhos refletem a diversidade temática, metodológica e institucional da área, abrangendo desde a patologia diagnóstica até estudos experimentais, patologia comparada, doenças infecciosas, patologia de animais de produção, de companhia e silvestres, entre outros temas relevantes. Os Anais do 6º CBPV representam, portanto, não apenas um registro científico do evento, mas também um testemunho do esforço coletivo de docentes, pesquisadores, estudantes e profissionais que, mesmo em um cenário adverso, mantiveram viva a produção científica e o compromisso com a excelência acadêmica. Que este material sirva como fonte de consulta, inspiração e fortalecimento contínuo da Patologia Veterinária no Brasil.
Supplement 2 - Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e XII Simpósio Brasileiro da Davis-Thompson Foundation
6º Congresso Brasileiro de Patologia Veterinária (6º CBPV)
XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE)
XII Simpósio Brasileiro da Davis-Thompson Foundation
Copyright (c) 2025 Brazilian Journal of Veterinary Pathology https://creativecommons.org/licenses/by/4.0
Metastatic canine cutaneous clear cell adnexal carcinoma: case report
Canine cutaneous clear cell adnexal carcinoma (CCCCAC) is a rare primary cutaneous adnexal neoplasm. Microscopically, CCCCAC is characterized by dermal and/or subcutaneous lobules of pleomorphic polygonal to spindle-shaped cells with clear, glycogen-rich cytoplasm containing variably sized vacuoles with indistinct borders frequently associated with peripheral palisading, follicular papillary mesenchymal body–like structures, comedonecrosis, and lymphovascular invasion. Despite aggressive microscopic features, the biological behavior of CCCCAC in dogs remains poorly defined, and metastatic rates are likely underestimated. This report describes a metastatic case of CCCCAC in an 11-year-old mixed-breed, neutered male dog presenting with a cervical cutaneous mass and progressive pulmonary and lymph node metastases. Fine-needle aspiration cytology supported the diagnosis of a malignant epithelial neoplasm. Histopathology revealed a multilobulated, poorly demarcated, infiltrative neoplasm composed of clear cells with marked pleomorphism, high mitotic activity, comedonecrosis, and extensive lymphovascular invasion. Histochemical staining demonstrated cytoplasmic glycogen accumulation by periodic acid–Schiff positivity with diastase sensitivity. Immunohistochemically, neoplastic cells showed diffuse cytoplasmic immunoreactivity for pan-cytokeratin, variable expression of vimentin and S-100, and absence of melan-A, smooth muscle actin, and thyroid transcription factor-1 labeling, confirming the diagnosis of CCCCAC. Disease progression occurred despite supportive care, and necropsy revealed marked local aggressiveness and widespread metastases to lymph nodes, lungs, parietal pleura, and pancreas. To the authors’ knowledge, this is the first documented case of metastatic CCCCAC in Brazil.
Transmural gastrointestinal stromal tumor of the mixed subtype in a canine: case report
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms originating from interstitial cells of Cajal, characterized, in most cases, by the immunohistochemical expression of c-Kit (CD117). In dogs, they are rare and the associated clinical signs are nonspecific, including vomiting, diarrhea, weight loss, and abdominal pain, which often makes clinical diagnosis difficult. This paper describes a case of GIST in a dog, located in the cecum, detected through imaging exams and diagnosed via anatomopathological evaluation, and immunohistochemical. Macroscopically, the mass was transmural and measured approximately 7.0 cm in diameter, white to dark brown in color, had a soft consistency, and, upon cutting, a smooth, solid surface. Microscopically, the neoplasm was predominantly composed of spindle cells, with multifocal areas of epithelioid cells, both with positive plasma membrane staining for c-Kit and absence of Desmin expression, confirming the diagnosis. This report reinforces the importance of immunohistochemical evaluation in differentiating GISTs from other mesenchymal neoplasms of the gastrointestinal tract and contributes to the understanding of the morphological and clinicopathological aspects of this entity in dogs.
Giant cutaneous horn associated with a dilated pore in a cat
This report aims to describe a rare case of a giant cutaneous horn in a domestic cat and its association with a dilated pore. A 6-year-old female domestic cat was presented to a veterinary clinic with a keratinized, horn-like lesion on the right lateral cheek. The cylindrical mass measured 9.5 cm in length, 1.5 cm in width, and 1.5 cm in thickness, and appeared firm, dark brown to black, and hyperkeratotic. Histopathological examination revealed a dermal cyst lined by well-differentiated squamous epithelium with a prominent granular layer, consistent with an infundibular origin. The cystic lumen contained compact, laminated, partially pigmented keratin, with focal areas of parakeratosis. The lesion was characterized by keratinocyte hyperplasia with extensive laminated parakeratotic hyperkeratosis. These findings led to the diagnosis of a dilated pore, a proliferative variant of the feline infundibular follicular cyst, associated with a giant cutaneous horn. This rare presentation not only provides insight into the pathogenesis and potential relationship between dilated pores and cutaneous horns in cats, but also expands the current understanding of their differential diagnoses, particularly in atypical locations such as the face.
Anais do 8º Congresso de Patologia Veterinária (CPV), XXII Encontro Nacional de Patologia Veterinária(ENAPAVE), XVI Simpósio Brasileiro da Davis-Thompson Foundation, VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e I Simpósio de Sanidade Animal do CRMV-MT
É com grande satisfação que apresentamos os anais do 8º Congresso de Patologia Veterinária (CPV), do XXII Encontro Nacional de Patologia Veterinária (ENAPAVE), do XVI Simpósio Brasileiro da Davis-Thompson Foundation, do VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e do I Simpósio de Sanidade Animal do CRMV-MT. Este magnífico evento ocorreu de 09 a 12 de setembro de 2025, no Centro de Eventos do Pantanal, em Cuiabá, Mato Grosso, Brasil. Estes eventos associados foram frutos de uma colaboração entre a Associação Brasileira de Patologia Veterinária (ABPV) e o Colégio Brasileiro de Patologia Animal (CBPA), contando com o valioso apoio da Davis-Thompson Foundation, da Universidade Federal do Mato Grosso, do Conselho Regional de Medicina Veterinária do Mato Grosso, além de grande número de patrocinadores, aos quais estendemos nossos sinceros agradecimentos. Após o sucesso do retorno à forma 100% presencial do Congresso de Patologia Veterinária (CPV) alcançado durante a sua sétima edição, em João Pessoa, em 2023, é com muito entusiasmo que venho como presidente da Associação Brasileira de Patologia Veterinária (ABPV), em nome da Diretoria 2024/2025, agradecer a todos pela massiva presença no 8º CPV, XXII ENAPAVE, em Cuiabá, Mato Grosso, Brasil. A região Centro Oeste carrega um forte laço com o precursor do CPV, nosso querido ENAPAVE. O primeiro ENAPAVE ocorreu em 1983, na Universidade Federal de Mato Grosso do Sul, em Campo Grande. Apesar do evento ter visitado nossa região em várias outras ocasiões: Campo grande 2001 e 2007, Goiânia 2011 e Brasília 2017, está foi a primeira vez que o CPV/ENAPAVE ocorreu na cidade de Cuiabá. Nossa cidade é reconhecida frequentemente como referência em altas temperaturas, mas mostramos, durante o evento, que nosso calor humano e acolhida é mais escaldante que as altas temperaturas de nossa cidade. O evento ocorreu entre os dias 09 e 12 de setembro de 2025, no Centro de Eventos do Pantanal, local climatizado e com ampla capacidade que pôde receber todos os congressistas e nossos parceiros com muito conforto e infraestrutura. Fico imensamente agradecido, pois em sua primeira edição em Cuiabá, o evento se tornou-se o maior ENAPAVE da história até este momento. Contamos com 26 palestrantes, 443 congressistas, além de 555 resumos em forma de pôster, 06 apresentações orais e 22 participações no fórum de lâminas. Os principais eixos temáticos abordados foram: Ensino em Patologia Veterinária, Patologia de animais de pequeno porte, Patologia de animais de grande porte e de produção, Patologia de animais exóticos e silvestres e Métodos de diagnóstico na patologia veterinária. As temáticas foram abordadas na forma de palestras e minicursos que foram ministrados por profissionais que realizam pesquisas na vanguarda do conhecimento. Dessa forma, o público participante teve a possibilidade de acessar informações sobre o que há de mais avançado, no tocante às inovações tecnológicas na patologia, possibilitando assim avanços na rotina de diagnóstico, ensino, pesquisa e extensão na área de patologia veterinária no país. O evento proporcionou interações pessoais, profissionais e científicas, ao propiciar um ambiente de network para troca de informações e construção de novos relacionamentos. Tivemos ainda, fazendo jus à fama de nossa cidade, uma “calorosa” programação social, destinada à confraternização de todos os participantes. Estamos felizes por atingir o sucesso pretendido e agradecemos a importante participação e confiança de todos os que, como nós, acreditam na educação técnico-científica como promotora de mudanças em prol da disseminação das melhores práticas em Patologia Veterinária. Nos vemos em Vitória-ES em 2027!!!
Supplement - Anais do 8º Congresso de Patologia Veterinária (CPV), XXII Encontro Nacional de Patologia Veterinária (ENAPAVE), XVI Simpósio Brasileiro da Davis-Thompson Foundation, VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e I Simpósio de Sanidade Animal do CRMV-MT
8º Congresso de Patologia Veterinária (CPV)
XXII Encontro Nacional de Patologia Veterinária (ENAPAVE)
XVI Simpósio Brasileiro da Davis-Thompson Foundation
VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP)
I Simpósio de Sanidade Animal do CRMV-MT
Pulmonary vascular amyloidosis in an aged dog
History: The carcass of a 14-year-old, female Boston Terrier was submitted for necropsy. The clinical history for the last year was dominated by recurrent and progressive episodes of dyspnea, stertor, and tachypnea. The patient had a prior history of a grade 3 cutaneous mast cell tumor that was excised years ago. Clinical investigations during the dog’s life included thoracic radiographs, which revealed a mild patchy interstitial pattern and tracheal collapse. The owner declined blood analysis and other diagnostics on several occasions due to financial constraints. The final episode was characterized by a severe respiratory crisis with oxygen saturation below 90%. Given the poor prognosis and the animal’s deteriorating condition, humane euthanasia was performed.
Fibrinosuppurative valvular endocarditis withmyxomatous valvular degeneration in a mare
Clinical History: A 12-year-old Azteca mare died unexpectedly with no premonitory clinical signs being observed.
History: A 10-year-old male neutered Golden Retriever dog presented for seizures and a tendency for clockwise circling. A large extra-axial homogenously contrast-enhancing mass was seen with magnetic resonance imaging in the right frontal lobe/olfactory bulb area extending into the nasal cavity. A transfrontal craniotomy with debulking was performed with cytological touch impressions and biopsy. Acute-onset focal seizures and episodes of compulsive circling started around 1 month following surgery, with regrowth of the extra-axial mass with secondary perilesional edema on imaging. Euthanasia was elected.