Brazilian Journal of Veterinary Pathology
The purpose of the BJVP, a peer-reviewed journal, is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.
Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e XII Simpósio Brasileiro da Davis-Thompson Foundation
É com grande satisfação que apresentamos os Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), realizado conjuntamente com o XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e o XII Simpósio Brasileiro da Davis-Thompson Foundation. Este importante evento científico ocorreu de forma totalmente remota, entre os dias 26 e 30 de julho de 2021, em um dos períodos mais desafiadores da história recente da humanidade, marcado pela pandemia da COVID-19. Mesmo diante das limitações impostas pelo distanciamento social e pelas incertezas daquele momento, o congresso demonstrou a força, a resiliência e o compromisso da comunidade científica da Patologia Veterinária com a produção e a disseminação do conhecimento. A realização do evento em formato virtual possibilitou ampla participação nacional e internacional, consolidando-se como um espaço plural de troca científica, atualização profissional e fortalecimento institucional da área. Esta edição do congresso contou com o maior número de palestrantes já registrado na história do CBPV, reunindo 67 especialistas provenientes de diferentes regiões do Brasil e de diversos países. Esses profissionais, mesmo vivenciando contextos locais igualmente desafiadores, aceitaram generosamente contribuir com o evento, compartilhando experiências, avanços científicos, abordagens diagnósticas e perspectivas futuras da Patologia Veterinária. Além das palestras, o evento recebeu um expressivo número de contribuições científicas, totalizando 301 resumos, apresentados na forma de pôsteres digitais, os quais estão reunidos nestes Anais. Os trabalhos refletem a diversidade temática, metodológica e institucional da área, abrangendo desde a patologia diagnóstica até estudos experimentais, patologia comparada, doenças infecciosas, patologia de animais de produção, de companhia e silvestres, entre outros temas relevantes. Os Anais do 6º CBPV representam, portanto, não apenas um registro científico do evento, mas também um testemunho do esforço coletivo de docentes, pesquisadores, estudantes e profissionais que, mesmo em um cenário adverso, mantiveram viva a produção científica e o compromisso com a excelência acadêmica. Que este material sirva como fonte de consulta, inspiração e fortalecimento contínuo da Patologia Veterinária no Brasil.
Supplement 2 - Anais do 6º Congresso Brasileiro de Patologia Veterinária (6º CBPV), XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE) e XII Simpósio Brasileiro da Davis-Thompson Foundation
6º Congresso Brasileiro de Patologia Veterinária (6º CBPV)
XX Encontro Nacional de Patologia Veterinária (XX ENAPAVE)
XII Simpósio Brasileiro da Davis-Thompson Foundation
Copyright (c) 2025 Brazilian Journal of Veterinary Pathology https://creativecommons.org/licenses/by/4.0
Anais do 8º Congresso de Patologia Veterinária (CPV), XXII Encontro Nacional de Patologia Veterinária(ENAPAVE), XVI Simpósio Brasileiro da Davis-Thompson Foundation, VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e I Simpósio de Sanidade Animal do CRMV-MT
É com grande satisfação que apresentamos os anais do 8º Congresso de Patologia Veterinária (CPV), do XXII Encontro Nacional de Patologia Veterinária (ENAPAVE), do XVI Simpósio Brasileiro da Davis-Thompson Foundation, do VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e do I Simpósio de Sanidade Animal do CRMV-MT. Este magnífico evento ocorreu de 09 a 12 de setembro de 2025, no Centro de Eventos do Pantanal, em Cuiabá, Mato Grosso, Brasil. Estes eventos associados foram frutos de uma colaboração entre a Associação Brasileira de Patologia Veterinária (ABPV) e o Colégio Brasileiro de Patologia Animal (CBPA), contando com o valioso apoio da Davis-Thompson Foundation, da Universidade Federal do Mato Grosso, do Conselho Regional de Medicina Veterinária do Mato Grosso, além de grande número de patrocinadores, aos quais estendemos nossos sinceros agradecimentos. Após o sucesso do retorno à forma 100% presencial do Congresso de Patologia Veterinária (CPV) alcançado durante a sua sétima edição, em João Pessoa, em 2023, é com muito entusiasmo que venho como presidente da Associação Brasileira de Patologia Veterinária (ABPV), em nome da Diretoria 2024/2025, agradecer a todos pela massiva presença no 8º CPV, XXII ENAPAVE, em Cuiabá, Mato Grosso, Brasil. A região Centro Oeste carrega um forte laço com o precursor do CPV, nosso querido ENAPAVE. O primeiro ENAPAVE ocorreu em 1983, na Universidade Federal de Mato Grosso do Sul, em Campo Grande. Apesar do evento ter visitado nossa região em várias outras ocasiões: Campo grande 2001 e 2007, Goiânia 2011 e Brasília 2017, está foi a primeira vez que o CPV/ENAPAVE ocorreu na cidade de Cuiabá. Nossa cidade é reconhecida frequentemente como referência em altas temperaturas, mas mostramos, durante o evento, que nosso calor humano e acolhida é mais escaldante que as altas temperaturas de nossa cidade. O evento ocorreu entre os dias 09 e 12 de setembro de 2025, no Centro de Eventos do Pantanal, local climatizado e com ampla capacidade que pôde receber todos os congressistas e nossos parceiros com muito conforto e infraestrutura. Fico imensamente agradecido, pois em sua primeira edição em Cuiabá, o evento se tornou-se o maior ENAPAVE da história até este momento. Contamos com 26 palestrantes, 443 congressistas, além de 555 resumos em forma de pôster, 06 apresentações orais e 22 participações no fórum de lâminas. Os principais eixos temáticos abordados foram: Ensino em Patologia Veterinária, Patologia de animais de pequeno porte, Patologia de animais de grande porte e de produção, Patologia de animais exóticos e silvestres e Métodos de diagnóstico na patologia veterinária. As temáticas foram abordadas na forma de palestras e minicursos que foram ministrados por profissionais que realizam pesquisas na vanguarda do conhecimento. Dessa forma, o público participante teve a possibilidade de acessar informações sobre o que há de mais avançado, no tocante às inovações tecnológicas na patologia, possibilitando assim avanços na rotina de diagnóstico, ensino, pesquisa e extensão na área de patologia veterinária no país. O evento proporcionou interações pessoais, profissionais e científicas, ao propiciar um ambiente de network para troca de informações e construção de novos relacionamentos. Tivemos ainda, fazendo jus à fama de nossa cidade, uma “calorosa” programação social, destinada à confraternização de todos os participantes. Estamos felizes por atingir o sucesso pretendido e agradecemos a importante participação e confiança de todos os que, como nós, acreditam na educação técnico-científica como promotora de mudanças em prol da disseminação das melhores práticas em Patologia Veterinária. Nos vemos em Vitória-ES em 2027!!!
Supplement - Anais do 8º Congresso de Patologia Veterinária (CPV), XXII Encontro Nacional de Patologia Veterinária (ENAPAVE), XVI Simpósio Brasileiro da Davis-Thompson Foundation, VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP) e I Simpósio de Sanidade Animal do CRMV-MT
8º Congresso de Patologia Veterinária (CPV)
XXII Encontro Nacional de Patologia Veterinária (ENAPAVE)
XVI Simpósio Brasileiro da Davis-Thompson Foundation
VII Encontro Internacional de Saúde Animal e Prevenção (ENISAP)
I Simpósio de Sanidade Animal do CRMV-MT
Pulmonary vascular amyloidosis in an aged dog
History: The carcass of a 14-year-old, female Boston Terrier was submitted for necropsy. The clinical history for the last year was dominated by recurrent and progressive episodes of dyspnea, stertor, and tachypnea. The patient had a prior history of a grade 3 cutaneous mast cell tumor that was excised years ago. Clinical investigations during the dog’s life included thoracic radiographs, which revealed a mild patchy interstitial pattern and tracheal collapse. The owner declined blood analysis and other diagnostics on several occasions due to financial constraints. The final episode was characterized by a severe respiratory crisis with oxygen saturation below 90%. Given the poor prognosis and the animal’s deteriorating condition, humane euthanasia was performed.
Fibrinosuppurative valvular endocarditis withmyxomatous valvular degeneration in a mare
Clinical History: A 12-year-old Azteca mare died unexpectedly with no premonitory clinical signs being observed.
History: A 10-year-old male neutered Golden Retriever dog presented for seizures and a tendency for clockwise circling. A large extra-axial homogenously contrast-enhancing mass was seen with magnetic resonance imaging in the right frontal lobe/olfactory bulb area extending into the nasal cavity. A transfrontal craniotomy with debulking was performed with cytological touch impressions and biopsy. Acute-onset focal seizures and episodes of compulsive circling started around 1 month following surgery, with regrowth of the extra-axial mass with secondary perilesional edema on imaging. Euthanasia was elected.
Acute colic secondary to sand enteropathy (sablosis) in a horse
History: A 24–year-old Stockhorse gelding presented for veterinary assessment after developing profuse watery diarrhea. The horse presented with a distended abdomen, decreased gut sounds on both quadrants on the left-hand side, absent gut sounds on the right-hand side and was hypothermic (36.8°C) with a heart rate of 44 bpm. The horse was drenched with water, paraffin oil and electrolytes via a nasogastric tube. No net reflux was obtained. Despite the administration of pain relief and sedation, the gelding’s heart rate continued to increase to 68 bpm. The gelding was transported to a referral service but died upon arrival.
History One hundred and fifty 5-month-old crossbred rabbits raised for meat production were examined at a slaughterhouse. No abnormalities were observed during ante-mortem inspection.
Uremic gastritis and calcium oxalate crystallization in a dog
Clinical History: A 7-year-old female intact Welsh Corgi mix was presented to emergency services for vomiting, diarrhea, inappetence, and lethargy. Over the last 24 to 48 hours, she vomited approximately 5 to 6 times a day.
Xanthogranulomatosis in an eclectus parrot
History: A 14-year-old female eclectus parrot was submitted for necropsy with a history of abdominal distension and weight gain,
Clinical History: A placenta from a mare following parturition was submitted for evaluation. The foal was reported to be unusually weak at birth but otherwise grossly normal with no clinical abnormalities. The mare was treated with antibiotics prior to parturition.
Parvovirosis in a margay (Leopardus wiedii)
Clinical History: Multiple tissue samples from various organs of a juvenile margay (Leopardus wiedii) were collected during necropsy. Before death, the animal exhibited severe weakness, vomiting, diarrhea, dehydration, abdominal discomfort, and marked leukopenia.
History: Nine, adult, female Boer goats were presented to the University of California, Davis, Veterinary Medical Teaching Hospital for timed artificial insemination. To synchronize their estrous cycles, the owner gave each doe 7.5 mg dinoprost tromethamine (Lutalyse®) intramuscularly 12 hours prior to presentation and 24 hours prior to removal of the doe’s progesterone controlled intravaginal drug release device (EAZI-BREED™ CIDR®). Approximately 52 hours after prostaglandin administration, one of the does delivered two live kids, one female and one male, without complication. The neonates were unexpectedly premature by approximately two weeks. Both kids exhibited bilateral, smooth swelling at the laryngotracheal junction and generalized alopecia. Both kids were euthanized, and they were sent to the UC Davis Anatomic Pathology Service for necropsy.
Ultimobranchial body cyst in a neonatal goat
History and clinical signs: A two-day-old black and white pygmy goat kid was presented to the California Animal Health and Food Safety Laboratory – San Bernardino Branch, for euthanasia and necropsy with a history of what appeared to be a fluctuant mass under the skin of the ventral side of the neck. On clinical examination, an approximately 10 cm in diameter, fluid-filled structure was palpated under the skin along the ventral aspect of the neck (Fig 1). The goat kid had pronounced dyspnea and distress particularly during palpation. Euthanasia was performed with an overdose of barbiturate and a full necropsy was performed.
Strangles and infarctive purpura hemorrhagica in a horse
History: A euthanized 23-year-old Quarter Horse gelding with an ~1-week history of fever (102.5°F), clear nasal discharge and lymphadenopathy was euthanized.
Heartworm in a southern tiger cat (Leopardus guttulus) in Santa Catarina, Brazil
<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Heartworm disease, caused by <span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Dirofilaria immitis<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">, is a vector-borne illness primarily affecting dogs but also documented in domestic and wild felines. In Brazil, a previous case was reported in a southern tiger cat (<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Leopardus guttulus<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">) in São Paulo. This report describes the first documented case of heartworm disease in a <span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Leopardus guttulus<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> in Santa Catarina, Brazil. An adult female southern tiger cat was found on a city road in Joinville and presented with hypothermia, apathy, respiratory distress, and weakness. Despite supportive treatment, the animal did not recover and ultimately succumbed to its injuries. Necropsy revealed hemoperitoneum and hypovolemic shock due to trauma, with bite-associated wounds. Additionally, seven adult nematodes identified as <span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">D. immitis<span class="TextRun SCXW94845773 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> were found in the right ventricle, pulmonary artery, and femoral artery. Histopathological examination confirmed intravascular microfilariae, pulmonary vascular hypertrophy, hepatic congestion, and cardiac fibrosis, findings consistent with heartworm disease and congestive heart failure. This case underscores the need for further studies on heartworm disease in wild felines and potential zoonotic risk in endemic regions.
Clinicopathologic features, tumor staging, and intratumoral inflammation in canine oral non-tonsillar squamous cell carcinomas
<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">Oral cancers, such as squamous cell carcinomas, constitute important diseases in veterinary patients, as they are <span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">frequently<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"> <span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">observed<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"> in pets. Their usually aggressive behavior makes it critical to characterize <span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">the clinicopathologic<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"> features that can provide useful data for decision-making. Recently, the importance of inflammatory cell infiltration in different tumor types has been highlighted due to its association with clinical findings and outcomes. Thus, this study aimed to evaluate clinicopathologic features in 62 cases of canine oral non-tonsillar squamous cell carcinomas, as well as to investigate tumor infiltration by inflammatory cells and its relation to clinical staging. Statistically significant result<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">s were <span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">observed<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"> when comparing neutrophil infiltration in stage 2 patients and animals presenting higher stages (3 and 4). Patients in stages 3 and 4 revealed lower neutrophil infiltration than stage 2 dogs. Histological grading showed differences in mitotic count between less differentiated and well/moderately differentiated neoplasms. Such features—especially those related to neutrophil infiltration and tumor staging—are relevant for the comprehension of non-tonsillar tumors, <span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">consequently<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"> aiding in decisi<span class="NormalTextRun SCXW165922511 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; color: #000000; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; font-size: 16px; font-style: normal; font-variant-ligatures: none; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">on-making in cases of canine oral squamous cell carcinoma in dogs.
Primary extraskeletal osteosarcoma of the omentum in a young dog
<span class="TextRun SCXW98606293 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Extraskeletal osteosarcoma (EOSA) is a rare and aggressive mesenchymal neoplasm in dogs, primarily affecting older animals, <span class="TextRun SCXW98606293 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">with the spleen being the most common site of involvement<span class="TextRun SCXW98606293 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">. This report describes a rare case of primary EOSA originating in the omentum of a 1-year-and-5-month-old spayed female dog, highlighting the role of immunohistochemistry, specifically the positive expression of vimentin and RUNX2, in confirming the tumor’s mesenchymal and osteoblastic origin. The tumor was inoperable, and treatment consisted of medical management with toceranib phosphate and losartan, with the addition of zoledronic acid following the detection of bone metastasis. The patient exhibited temporary clinical improvement for 90 days, after which disease progression was noted, including the development of abdominal effusion (1.2 liters drained). The patient survived for 180 days following diagnosis, without adverse effects related to the treatment. Necropsy confirmed widespread metastases from fibroblastic osteosarcoma, including the skin, peritoneum, lungs, heart, liver, lymph nodes, and brain, with cerebral hemorrhage as the likely cause of sudden death. Histopathological evaluation revealed extensive areas of osteoid matrix and proliferating mesenchymal cells in a disorganized arrangement, with marked vascular invasion by neoplastic emboli, as well as multifocal hemorrhage and tumor necrosis. This <span class="TextRun SCXW98606293 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0e101a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">case illustrates a rare presentation of EOSA in a young dog and emphasizes the importance of including neoplasia in the differential diagnosis of abdominal masses, regardless of patient age. It also highlights the diagnostic value of immunohistochemical markers, particularly RUNX2, in distinguishing EOSA from other mesenchymal or reactive proliferations.
Cholangiocarcinoma with splenic metastasis in a red-tailed amazon (Amazona brasiliensis)
<span class="TextRun SCXW92899008 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="auto">Cholangiocarcinoma is a tumor originating from the epithelium of the biliary ducts that has been frequently reported in birds, particularly within the order Psittaciformes. A red-tailed amazon (<span class="TextRun SCXW92899008 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="auto">Amazona brasiliensis<span class="TextRun SCXW92899008 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="auto">) was voluntarily delivered to the Centro de Triagem e Recuperação de Animais Silvestres (CETRAS), in the Parque Ecológico do Tietê (São Paulo municipality, São Paulo state, Brazil), showing signs of prostration and respiratory distress. Despite supportive care, the bird died seven days after admission. Necropsy revealed cachexia and multiple small yellowish nodules scattered across the hepatic surface and extending into the parenchyma. Histopathological examination of the liver showed epithelial cell proliferation forming tubular structures within a moderately collagenous stroma, suggestive of cholangiocarcinoma. Immunohistochemical analysis of hepatic tissue was performed using a diagnostic panel including AE1/AE3, CK7, and HepPar-1. Only AE1/AE3 yielded a positive result, confirming the diagnosis of cholangiocarcinoma. This is the first report of cholangiocarcinoma in a red-tailed amazon. We highlight the importance of proper nutritional management to reduce the likelihood of neoplastic disease development, thus improving quality of life and increasing life expectancy in captive birds.
Neurotuberculosis in a Holstein-Friesian Calf from the State of Rio Grande do Sul, Brazil
<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Bovine tuberculosis is a chronic granulomatous disease caused by <span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Mycobacterium<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> <span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">tuberculosis<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> var <span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">bovis<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">. Despite control programs, bovine tuberculosis presents a significant challenge worldwide and it remains a concern in Brazil. Neurotuberculosis is a relatively rare form of the disease in which <span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Mycobacterium<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> reaches the central nervous system, leading to the formation of multiple small granulomas on the meningeal surface. This study reports a case of neurotuberculosis in an 8-month-old Holstein-Friesian calf from the state of Rio Grande do Sul, southern Brazil. The clinical course was chronic, of nearly five months, and clinical signs were mainly neurological, including ataxia, motor incoordination, stiff neck, muscular tremors, and seizures. These clinical signs resulted from granulomatous lesions affecting the central nervous system. Similar granulomas were also present in the lungs, mediastinal and mesenteric lymph nodes, and adrenal glands. Histologically the granulomas were characterized by caseous necrosis associated to inflammatory infiltration of epithelioid macrophages, Langhans multinucleated giant cells, lymphocytes, and plasma cells, proliferation of fibrous tissue, as well as occasional mineralization. Ziehl-Neelsen staining method yielded acid-alcohol resistant bacilli amidst necrotic debris and in the cytoplasm of Langhans cells. Clinic-pathological findings, <span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">postmortem<span class="TextRun SCXW227609535 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 48px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none"> and histological examinations, along with Ziehl-Neelsen staining, confirmed the diagnosis of neurotuberculosis in the present case. This report highlights the importance of control measures for tuberculosis, given the debilitating and zoonotic nature of the disease and the lack of effective treatment.
Frederico Heinz da Rocha Santos Schimdt Wiggers
Causes of death in captive Psittaciformes in the Jaboticabal region, Brazil (2014-2024)
<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">The necropsy of pet birds is an important tool for determining the cause of death and for identifying potential zoonotic or non-zoonotic etiological agents related to fatality. This retrospective study (2014 to 2024) aims to identify the main causes of death in Psittaciformes kept under human care in the Jaboticabal/SP region, Brazil. A total of 146 necropsy cases and histopathological analyses archived at the Wildlife Pathology Service of São Paulo State University, Jaboticabal campus, were examined. The most prevalently analyzed species included <span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Amazona aestiva<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">, <span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Nymphicus hollandicus<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">, and <span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Ara ararauna<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">, with a higher prevalence of adult birds and those from household environments. Causes of death were classified into infectious and non-infectious processes. Metabolic conditions, such as atherosclerosis, were the leading cause of death (14.3%), followed by trauma and poisonings. Among infectious causes, parasites of the genus <span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; font-style: italic; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">Paratanaisia<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">, as well as bacterial and<span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="auto"> <span class="TextRun SCXW118914361 BCX8" lang="EN-US" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-variant-ligatures: none !important; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; color: #0d0f1a; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif;" xml:lang="EN-US" data-contrast="none">fungal infections, were prominent. Difficulties in isolating infectious agents and carcass autolysis limited some diagnoses. The study reinforces the importance of necropsy as a diagnostic tool and highlights the need for preventive management practices tailored to birds in households, breeding facilities, and zoos. The findings highlight the importance of monitoring pre-mortem factors and implementing targetd preventive medicine strategies to improve the well-being and longevity of captive Psittaciformes.<span class="EOP SCXW118914361 BCX8" style="-webkit-user-drag: none; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; user-select: text; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 37px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; font-size: 12pt; line-height: 36px; font-family: 'Times New Roman', 'Times New Roman_EmbeddedFont', 'Times New Roman_MSFontService', serif; color: #0d0f1a;" data-ccp-props="{"201341983":0,"335551550":6,"335551620":6,"335559731":567,"335559740":480,"469777462":[1417],"469777927":[0],"469777928":[1]}">
A case of systemic pulmonary collaterals in a Doberman Pinscher with dilated cardiomyopathy phenotype
Dilated cardiomyopathy (DCM) in dogs is a common hereditary primary myocardial disease affecting large and giant breeds, predominantly Doberman Pinschers. This pathology is associated with mechanical and electrophysiological dysfunction of the myocardium, which is manifested by inadequate ventricular eccentric hypertrophy. Our report focuses on the case of unusual systemic pulmonary collaterals in a Doberman Pinscher with DCM phenotype. Cardiologic data have shown that myocardial histologic changes may be secondary to the presence of pulmonary collaterals and their potential influence on the development of left ventricular volume overload. Thus, we had every reason to believe that the volume overload that caused the development of congestive heart failure in this dog and possibly sudden cardiac death was caused by the presence of a combined arterial malformation. This case illustrates that atypical bypass manifestations detected during echocardiography can be further evaluated using computed tomography and angiography to further characterize and identify concomitant vascular abnormalities that might otherwise be masked or overlooked, especially when LV volume overload occurs in breeds predisposed to DCM. The research team considers it very important to publish such cases, as this will help the entire veterinary community quickly accumulate knowledge and experience for diagnostic and treatment of similar and other cases.
Canine myxoid mesothelioma with clinical presentation of Pseudomixoma peritonei
Myxoid mesothelioma is a rare variant of mesothelioma, characterized by a myxoid component, which refers to a gelatinous extracellular matrix containing mucin. This study describes a case of myxoid mesothelioma in a 13-year-old Yorkshire Terrier that presented with sudden abdominal distension, pain, and respiratory discomfort. Imaging exams revealed an extensive amount of amorphous, homogeneous, and viscous material in the abdominal cavity. Due to unsuccessful drainage attempts, exploratory laparoscopy was performed, uncovering large volumes of gelatinous material and areas of mesenteric thickness. Despite intensive care, the animal died post-surgery and was submitted for necropsy. Gross examination revealed diffuse gelatinous material coating the omentum and mesentery, along with firm micronodular areas. Microscopic analysis showed neoplastic sarcomatoid to round cells supported by delicate fibrovascular connective tissue with abundant myxoid stroma. Marked anisocytosis, anisokaryosis and cellular pleomorphism were observed; the myxoid nature of the stroma was confirmed by intense Alcian blue staining. Immunohistochemistry revealed positive vimentin and WT1 immunoreactivity, confirming the mesothelial origin of the tumor, while pancytokeratin, carcioembryonic antigen, high molecular weight cytoqueratin, and calretinin were negative. These findings support the diagnosis of myxoid-variant mesothelioma with clinical presentation of Pseudomyxoma peritonei.
Canine large t-cell intravascular lymphoma – report of two cases
Intravascular lymphoma is rare in all species and is characterized by the intravascular proliferation of neoplastic lymphocytes, with the central nervous system being the most affected site. The aim was to report two cases of dogs diagnosed with large T-cell intravascular lymphoma. Both dogs showed neurological signs, including ataxia, seizures, and difficulty walking. Macroscopically, malacia in the brain were noted. Microscopically, there was a predominance of large neoplastic lymphocytes within the vasculature, with CD3 positive and negative to CD20, CD79a, PAX-5 immunohistochemical staining, confirming large T-cell intravascular lymphoma. The complexity of this neoplasm highlights the importance of interdisciplinary collaboration among veterinarians for differential diagnosis of central nervous system diseases.
Copyright (c) 2025 Brazilian Journal of Veterinary Pathology
Toxoplasma encephilitis in a Collared Peccary (Dicotyles tajacu): clinical and pathological findings
Toxoplasmosis is a widespread zoonosis affecting numerous mammalian species. Wild suoids have been confirmed as susceptible hosts of Toxoplasma spp., and their meat is frequently consumed by hunters, their families, and domestic dogs, posing a growing foodborne risk in South America. We conducted a pathological study on a young captive Collared Peccary that showed neurological signs. Severe brain lesions were observed, including parenchymal necrosis with demyelination, gliosis, meningitis, and perivascular cuffing. Toxoplasma cysts containing tachyzoites, as well as free tachyzoites, were identified within these lesions. Additionally, focal necrosis with inflammatory infiltration was noted in the liver and heart, along with marked pulmonary edema. Immunohistochemistry for canine distemper virus in the brain was negative. To the best of our knowledge, this is the first report detailing the pathological findings of T. gondii infection in a wild suoid (Dicotyles tajacu).
Benign sebaceous gland tumor in a giant otter (Pteronura brasiliensis)
The giant otter (Pteronura brasiliensis) is the largest species in the Mustelidae family currently found on the Amazon, Cerrado, and Pantanal biomes, characterized by its semi-aquatic lifestyle. Globally classified as endangered, the species faces multiple anthropogenic threats, including illegal hunting, habitat destruction, human-wildlife conflicts, hydroelectric dam construction, pollution, and increased tourism activities that disturb its natural behavior and environment. This case report describes a sebaceous gland tumor in a giant otter housed in a zoological park in São Paulo state, Brazil. The animal exhibited discomfort and difficulty eating due to a neoformation in the labial commissure. Following a veterinary examination, the mass was surgically removed, and the otter recovered successfully, returning to its enclosure without complications. Histopathological analysis confirmed a benign sebaceous gland tumor, representing the first documented case in this species under human care. Further research on neoplasms in wild animals is essential to understanding cancer development, prevalence, and implications for conservation and veterinary medicine.
Primary and metastatic alveolar rhabdomyosarcoma: clinical case reports in canines from the Peruvian Amazon
This report presents four cases of alveolar rhabdomyosarcoma in canines, affecting the striated muscular tissues of the rostral skin, mandible, uterus, and multiple metastases. These cases were treated at veterinary clinics across the San Martín region (provinces of San Martín, Moyobamba, and Tocache), Peru, from a total of 118 neoplastic cases diagnosed histopathologically at the Animal Histopathology Laboratory of the Professional School of Veterinary Medicine, National University of San Martín, between 2020 and 2024. Diagnosing alveolar rhabdomyosarcoma requires a combination of histopathological analysis, immunohistochemical markers, and molecular techniques to distinguish it from other neoplastic variants. These cases highlight the importance of histopathological analysis, appropriate selection of chemotherapy or surgical resection, owner compliance, and the limitations of empirical therapies which, in the absence of a diagnostic foundation, often lead to recurrence and treatment failure in tumor management. In recent years, cytological and histopathological diagnosis has become a key resource in the San Martín region, contributing significantly to therapeutic decision-making and the prognostic evaluation of various types of canine neoplasms.
First report of gastroschisis in black-eared opossum (Didelphis aurita)
Black-eared opossums (Didelphis aurita) are neotropical marsupials least concern with extinction in Brazil. Pathologies involving this species are rarely described, and gastroschisis has never been reported before. This study aims to report a case of gastroschisis in a black-eared opossum newborn and describe the main characteristics observed. A newborn black-eared opossum in the developmental stage in marsupial pouch was received lifeless by Núcleo de Estudos e Pesquisas em Animais Selvagens (NEPAS) of Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF). The animal was examined externally, and herniated intestinal loops were observed without the presence of the peritoneum covering them, indicating gastroschisis. This report aims to contribute to the literature on small marsupial medicine by describing the occurrence of this malformation in an individual of D. aurita.
Angiostrongylus vasorum infection in a fox
A juvenile, gray fox arrived at the zoo with dehydration, depression and poor body condition. He died the day after arrival.
A 6.5-year-old spayed female domestic toy rabbit (Oryctolagus cuniculus) presented with a history of apathy, weight loss for approximately 2 weeks and paralysis of both hind limbs. Due to the worsening of its condition and poor prognosis, the rabbit was euthanized.
Bursal cryptosporidiosis in a kelp gull (Larus dominicanus)
A juvenile kelp gull (Larus dominicanus) was found dead.