v.11, n.3, 1
Original Full Paper
Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
Raul E. Marin, Carlos Schild, Juan A. Garcia, German J. Canton, Juan Micheloud, Eleonora L. Morrell, Francisco A. Uzal
Abstract
Five Aberdeen Angus calves were inoculated intra-ruminally with ground seeds of Ricinus communis at doses of 1, 1.5, 2 or 3 gr per kg of body weight, or with saline solution (control), respectively. Grossly, all intoxicated animals showed hemorrhages in abdominal serosas, epicardium, endocardium, spleen, pre-stomachs, abomasum, and small and large intestine, and diffuse edema of the ruminal mucosa. Microscopically, in all animals inoculated with R. communis seeds, the main feature was the presence of pyknotic and karyorrhectic nuclei in the endothelium of central nervous system, hepatic, ruminal, intestinal, glomerular and alveolar capillaries, and in lymphoid cells of multiple organs. Apoptosis, confirmed by activated caspase-3 immunohistochemistry, was observed in these cells. No gross or microscopic lesions were observed in the control animal. The results of this study suggest that apoptosis is the main mechanism of cell death in cattle intoxicated with R. communis seeds.
Key words: apoptosis, cattle, experimental intoxication, Ricinus communis.
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DOI: 10.24070/bjvp.1983-0246.v11i3p86-91
v.11, n.3, 2
Case Report
Rhinosporidiosis in a dog from Uruguay and review of the literature
Claudio Borteiro, Javier Etcheverze, Natalia de León, Carina Nieto, Mailén Arleo, Claudio Martínez Debat, Francisco Kolenc, Martín Ubilla, Jorge Freire, Fernando Dutra
Abstract
We report a case of nasal rhinosporidiosis in a dog native to Uruguay, being the sixth report of Rhinosporidium seeberi infection in this host from South America. Diagnosis was made by histopathology of biopsied tissue and specific PCR assay from nasal swab material. The patient was a 3-year-old male dog, of the Dogo Argentino breed, living in a rural area in southeastern Uruguay. An account of published cases in dogs worldwide is provided. As seen in other hosts, male dogs seem to present a predisposition for acquiring the disease.
Key words: canine, nasal granuloma, Rhinosporidium seeberi, Dermocystida.
Download full article: v11 n3 – 2
DOI: 10.24070/bjvp.1983-0246.v11i3p92-96
v.11, n.3, 3
Case Report
Mandibular squamous cell carcinoma in a captive Siberian tiger (Panthera tigris altaica)
Ayisa R. de Oliveira, Tatiane F. de Carvalho, Alexandre Arenales, Herlandes P. Tinoco, Carlyle M. Coelho, Maria Elvira L. T. Costa, Tatiane A. Paixão, Eduardo A. Caixeta, Guilherme R. G. Pinheiro, Renato L. Santos
Abstract
Squamous cell carcinoma (SCC) is a common oral neoplasm in domestic cats, but there are only a few reports in wild felids. A captive 10-years-old, female Siberian tiger (Panthera tigris altaica), with history of chronic renal disease and serologically positive for Leishmania sp. developed a lytic mandibular nodule that was histologically diagnosed as SCC. At necropsy was also observed an exocrine pancreatic carcinoma, which was considered an incidental finding, and a chronic lympho-plasmocytic interstitial nephritis associated with a membranous glomerulopathy, compatible with the chronic renal disease presented by the animal. To the best of our knowledge this is the first report of an invasive and non-metastatic mandibular SCC in a Siberian tiger.
Key words: SCC, oral neoplasia, wild felid, pancreatic carcinoma, leishmaniasis.
Download full article: v11 n3 – 3
DOI: 10.24070/bjvp.1983-0246.v11i3p97-101
v.11, n.3, 4
Case Report
Primary diffuse mammary hemangiosarcoma in a female dog
Antônio F. Leis Filho, Patricia F. Lainetti, Marina A. Cyrino, Priscila E. Kobayashi, Camila D. Costa, Laíza S. Camargo, Fabiana F. Souza, Renée Laufer-Amorim, Carlos E. Fonseca-Alves
Abstract
In veterinary medicine, primary mammary hemangiosarcoma is a very rare disease and there was no previous report describing the disease in dogs. Herein, we describe necropsy findings of a female dog, which presented a diffuse mammary hemangiosarcoma affecting the mammary gland. A diffuse irregular plaque was found in all mammary gland, involving the whole mammary gland tissue. The histopathological evaluation revealed neoplastic cells with an ovoid to spindle shaped basophilic and numerous atypical neoplastic tumor cells forming vascular structures. There was no glandular proliferation and no changes in the superficial dermis and no neoplastic emboli in the lymph vessels. Immunohistochemistry for vimentin, pan-cytokeratin, CK8/18 and CD31 was conducted. Positive expression was found to the pan-cytokeratin and CK8/18 by remaining epithelial cells confirmed the luminal mammary origin. Vimentin and CD31 positive expression by neoplastic cells confirmed the endothelial origin of the neoplasia. The histopathological and immunohistochemical findings supported the diagnosis of a primary mammary hemangiosarcoma.
Key words: dog, mammary neoplasia, angiosarcoma, endothelial cells, neoplasia.
Download full article: v11 n3 – 4
DOI: 10.24070/bjvp.1983-0246.v11i3p102-107
v.11, n.3, 5
Case Report
Pulmonary adenocarcinoma in mare
Mayane Faccin, Filipe K. Cestari, Mônica R. Matos, João Pedro Cavasin, Anna Zimmermann, Flávio H. Carvalho, Geane M. Pagliosa, Aline M. Viott
Abstract
Primary lung neoplasms are infrequent in veterinary medicine, particularly in large animals. The most frequently affected species are dogs and cats. These neoplasias are usually malignant and the adenocarcinoma type is the most frequent. This paper describes a case of pulmonary adenocarcinoma in a mare, including its pathological and immunohistochemical features. The animal had natural death and was submitted for necropsy. Diffuse jaundice, splenomegaly due to red pulp hyperplasia, pulmonary edema and congestion were observed. Cytological evaluation of the spleen revealed intracytoplasmatic structures in erythrocytes, compatible with Babesia sp. Histopathology of the lung revealed a neoplastic proliferation of epithelial cells, forming acinar and tubular structures supported by a fibrovascular stroma. Immunohistochemistry of such lesions was positive for cytokeratin and napsin A, negative for vimentin and thyroid transcription factor 1, corroborating the diagnosis of adenocarcinoma. Lung carcinomas in equines are described in animals ranging from four to 23 years old, without breed or sex predisposition. Clinical signs, when present, are related to the compromise of respiratory function, which was not observed in the present case. Pulmonary neoplasms must be considered among the diagnostics of chronic respiratory diseases. Histopathological and immunohistochemistry exams are highly valuable for classification of primary lung neoplasms.
Key words: carcinoma, pulmonary, primary pulmonary neoplasm.
Download full article: v11 n3 – 5
DOI: 10.24070/bjvp.1983-0246.v11i3p108-112
v.11, n.3, 6
Case Report
Papillary renal adenoma in a toco toucan (Ramphastos toco)
Alexandre Arenales, Frank A. de O. Toledo, Ayisa R. de Oliveira, Nayara F. de Paula, Lucas B. S. de Oliveira, Carlyle M. Coelho, Herlandes P. Tinoco, Renato L. Santos
Abstract
Primary renal neoplasms are infrequent in domestic animals and birds, being budgerigars an exception. This report describes a papillary renal adenoma in a toco toucan (Ramphastos toco), which was euthanized due to poor prognosis after surgical intervention of phalanx fractures in both wings. Grossly, the caudal pole of the right kidney had a nodular lesion measuring 3.5 x 1.7 x 1.5 cm. Microscopically, there was a well delimited neoplasm arranged in large and coalescent papillary structures composed by a single layer of epithelial cells. There was mild to moderate nuclear and cytoplasmic pleomorphism, whereas mitotic figures were absent. In conclusion, this tumor was considered as an accidental finding, which is similar to the majority of adenomas reported in domestic mammals.
Key words: zoo, renal tumor, avian oncology, wild animals, birds.
Download full article: v11 n3 – 6