v.14, n.3, 9

Case Report

Metronomic chemotherapy for advanced diffuse hepatocellular carcinoma in a dog

Paloma Helena Sanches da Silva, Mayara Coutinho Carlos de Souza, Ellen Bethânia de Oliveira Cavalcanti, Victoria Bringhenti Fonseca, Tatiany Luiza Silveira, Mayra Cunha Flecher, Geovanni Dantas Cassali & Rodrigo dos Santos Horta

Abstract:

Primary liver tumors represent 0.6% to 1.3% of neoplasms in dogs. Hepatocellular carcinoma (HCC) is the most common liver tumor. It is divided into three morphological groups: massive, nodular and diffuse. The presumptive diagnosis is made through imaging tests, such as ultrasound, although confirmation is made by histopathology. Surgery remains the treatment of choice for massive tumors, but there is no standard treatment for nodular and diffuse forms. This study aimed to report a case of prolonged survival in a dog with diffuse HCC, treated with metronomic chemotherapy and palliative care including non-steroidal anti-inflammatory and low-dose naltrexone.

Keywords: Dog; Liver, Neoplasm, Metronomic Chemotherapy, Chlorambucil, Low-dose naltrexone.

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DOI: 10.24070/bjvp.1983-0246.v14i3p199-205